"Efficient process development requires forward thinking combined with DoE, a scalable platform and predictive small-scale modeling. These are principles I’m excited to translate into cutting-edge ATMP facility designs that take advantage of the latest process innovations and modeling tools to optimize efficiencies and deliver a design that is fit for purpose and supports future process evolution."
Mr. Todorov has over 10 years of industry experience with early- to late-stage process development programs, contributing to IND-enabling studies, supporting external partnerships and consulting in the cell therapy and AAV gene therapy space. Prior to joining IPS, he strategically led the development of novel AAV manufacturing and analytical platforms through the evaluation of new technologies and continuous process improvement projects. George developed and implemented an AAV process scale-up for transient expression systems in mammalian cells, leveraging DOE yield optimization studies.
His hands-on and consulting experience includes designing and coordinating laboratory expansions and GMP facilities for various cell therapy and AAV process scale-up operations. George is a meticulous, inquisitive, and data-driven leader focused on empowering and developing teams and organizations. He has trained and managed technical staff in AAV process development and production spanning cell thaw to final formulation.
Education
- M.S. - Biotechnology, University of California, Irvine
- B.S. - Biological Sciences, University of California, Santa Barbara
Professional Associations
- ISPE - International Society for Pharmaceutical Engineering
- American Society for Gene and Cell Therapy (ASGCT)
Industry Experience
- Adverum Biotechnologies, Inc.
- Allergan, Inc.
Publications
- Todorov, George. “Cell and Ex Vivo Gene Therapies: A Manufacturing Odyssey.” The Medicine Maker Online, December 2022.
- Todorov, George, Catherine Jomary, PhD. “What Improvements Do We Need to See in Cell and Gene Supply Chains?” Cell & Gene Online, November 2022.
- Todorov, George, et. al. “Process Engineering and Industrial Modeling Collaboration Delivers Improved Efficiency and Facility Throughput.” Pharmaceutical Engineering Online, November 2021.
- Todorov, George, et. al. “Process Engineering and Industrial Modeling Collaboration Delivers Improved Efficiency and Facility Throughput.” Cell & Gene, September 2021.
- Todorov, George, et. al. “Response Surface Methods Point the Way to Higher rAAV Yields at Lower Levels of Transfection Reagent.” Genetic Engineering & Biotechnology News, May 2020.
- Todorov, Gueorgui, et. al. “Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease.” Proceedings of the National Academy of Sciences of the USA, 108 (44), November 2011.
Presentations
- Todorov, George et. al. “Paving the Road to Allogeneic CAR Therapy Manufacturing; a Case Study from a Commercial Facility Design.” CAR-TCR Summit, September 2022, Boston, MA.
- Todorov, George. “Picking the Right Cell Therapy Culture System.” INTERPHEX, October 2021, New York, NY.
- Todorov, George, et. al. “Designing Practical and Flexible CDMO Manufacturing Suites and Integrated Facilities to Accommodate the Evolving Landscape of Cell Therapy Processes.” CAR-TCR Summit, August 2021, Virtual.
- Todorov, Gueorgui, et. al. “Large scale suspension production of AAV capsid variant libraries from stable recombinant HEK293 cell banks.” American Society of Gene and Cell Therapy, May 2020, Boston, MA.
- Todorov, Gueorgui, et. al. “Poster - Biodistribution and pharmacokinetics of AAVrh.10-A1AT mediated gene therapy in humanized-liver mice as a predictor of A1AT human expression levels following intravenous delivery.” ESGCT/SETGYC Collaborative Congress, October 2019, Barcelona, Spain.
- Todorov, Gueorgui, et. al. “Poster - In vivo screening of an adeno-associated virus capsid library in non-human primate eyes identifies a novel AAV variant with superior retinal penetration and transduction by intravitreal delivery.” ESGCT/SETGYC Collaborative Congress, October 2019, Barcelona, Spain.
- Todorov, Gueorgui. “Tinkering the Capsid – From Concept to Clinic.” Sacramento State University Invited Lecture Series, April 2019, Sacramento, CA.
- Todorov, Gueorgui, et. al. “Poster - Evaluating AAV Hybrid Variants for Improved Tropism after Intravitreal Gene Delivery to the Retina.” American Society of Gene and Cell Therapy Meeting, May 2015, Chicago, IL.
