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Projects

Large-scale mAb Manufacturing Facility

Confidential Client, Northeast, United States

Large-scale mAb Manufacturing Facility
Large-scale mAb Manufacturing Facility
Projects

Large-scale mAb Manufacturing Facility

Confidential Client, Northeast, United States

IPS performed design, engineering, construction management, and commissioning to fit out an existing building shell with a 20,000L mAb manufacturing facility. 

The client was contracted by their key customer to rapidly develop a backup supply of a critical, high value mAb. IPS provided conceptual and preliminary engineering, detailed design, permitting, equipment and subcontract procurement, construction management, and commissioning.

The scope was fast-track and included multi-story equipment general arrangements and renderings, cost estimates, and life cycle project schedule. The facility was completed, concept through commissioning, in 24 months and included the following functions:

Fermentation & Media

  • Media prep operations gravity flowing into fermentation
  • Disposable inoculation and seed reactors up to 2KL
  • Stainless steel production bioreactor systems

Harvest

  • Centrifuge, depth filters, final filters and harvest vessel

Buffer Hold

  • Disposable bag and transfer systems to feed purification via gravity
  • Material handling systems capable of safe bag movement throughout the facility

Purification and Bulk Fill

  • Purification equipment and bulk fill into two suites (pre and post viral)
  • Column packing in pre/post viral purification available

Utilities

  • Dirty utilities installation capable to meet the needs of the customer dedicated suite with redundancy capability
  • Clean utilities installed as units serving only this customer dedicated suite.

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