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Insights

Handling Hidden Scale-Up Hazards

Jan 02, 2014

Insights

Handling Hidden Scale-Up Hazards

Jan 02, 2014

Technicians deal with hazards on a daily basis, and so it would make sense that the earlier in the development process that hazards can be considered, the better. Certainly during scale-up, your project team will need to consider: Will I need to explore different material handling techniques because of the increased scaled-up volume of the API? If a successful Phase II or III project uses hazardous or flammable solvents, what are the operational risks associated with scaling the batch volume up to 100 or 1000 times?

To read more go to http://digital.pharmpro.com/pharmaceuticalproducts/january_february_2014/?pm=2&u1=friend&pg=22#pg22

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